Recent News

The Role of Inflammation in Pre-leukemia Stem Cell Evolution

Since stem cells can continually self-regenerate, making more stem cells, and differentiate into many different specialized cell types, they play an important role in human development and human health. But there can also be a dark side -- stem cells can sometimes become cancer stem cells, proliferating out of control and leading to blood cancers, such as leukemia and multiple myeloma. Our analyses were the first to show that, in response to inflammation, two enzymes called APOBEC3C and ADAR1 work together to fuel the transition from pre-cancer stem cells to cancer stem cells in leukemia. Read More | Publication

Catalysing New Thinking on the Development of Cancer

For years, research has focussed on DNA mutations as the driving cause of cancer. Analysis of 20 known cancer-causing chemicals in our environment with their corresponding mutational signature in mouse DNA reveals that while all 20 chemicals caused cancer, only 3 left a distinct pattern of somatic mutations. These results could ultimately transform our understanding of cancer development as well as our ability to prevent and treat human cancer. Read More | Publication

Most Comprehensive Map of Mutational Signatures in Cancer

The largest ever study to analyze entire tumor genomes has provided the most complete picture yet of how DNA glitches drive tumor cell growth. We examined almost 25,000 cancer patients to identify the mutational signatures of the processes that causes the cancers in these patients. Our analysis revealed a multitude of avenues for cancer treatment and cancer prevention and provided a reference set of mutational signatures for the foreseeable future. Read More | Publication